11
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11375 | GCN2iB | Others , Autophagy | |
GCN2iB is an ATP-competitive inhibitor of a serine/threonine-protein kinase general control nonderepressible 2 (GCN2), with an IC50 of 2.4 nM. | |||
T1742 | 4E1rcat | PERK , Autophagy | |
4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM. | |||
T14044 | 4E2RCat | PERK | |
4E2RCat is an eIF4E-eIF4G interaction inhibitor (IC50: 13.5 μM). | |||
T11374 | GCN2-IN-6 | Others , PERK | |
GCN2-IN-6 is also a eIF2α kinase PERK inhibitor with an IC50 of 0.26 nM (in enzymatic assay) and 230 nM (in cells). GCN2-IN-6 is a potent, and orally available GCN2 inhibitor confirmed by in-house enzymatic (IC50 of 1.8... | |||
T2665 | 4EGI-1 | 4EGI 1 | Apoptosis , PERK , Autophagy |
4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM). | |||
T3207 | Briciclib | ON 014185 | CDK , PERK , Autophagy |
Briciclib (ON 014185) is a small molecule that suppresses cyclin D1 accumulation in Y cells. | |||
T11373 | GCN2-IN-1 | A-92 | Others |
GCN2-IN-1 (A-92) is an effective GCN2 inhibitor and can be used in research on the treatment of cancer as a chemotherapeutic agent. | |||
T9149 | 2BAct | 2B-Act,2B Act | PERK |
2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response | |||
TQ0131 | Rocaglamide | Rocaglamide A,Roc-A | HSP , NF-κB , PERK |
Rocaglamide (Roc-A), isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB activation in T-cells. | |||
T5173 | SBI-0640756 | SBI 0640756,SBI-756 | PERK , Autophagy |
SBI-0640756 (SBI-756) (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. | |||
TP2247 | eukaryotic translation initiation factor 3 | Others | |
Eukaryotic initiation factors (eIF) are proteins involved in the initiation phase of eukaryotic translation. Eukaryotic translation initiation factor 3 binds to the ribosome subunit-mRNA complex. It has been implicated i... |