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Search Results for " eukaryotic initiation factor (eif) "

11

Compounds

Cat No. Product Name Synonyms Targets
T11375 GCN2iB Others , Autophagy
GCN2iB is an ATP-competitive inhibitor of a serine/threonine-protein kinase general control nonderepressible 2 (GCN2), with an IC50 of 2.4 nM.
T1742 4E1rcat PERK , Autophagy
4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.
T14044 4E2RCat PERK
4E2RCat is an eIF4E-eIF4G interaction inhibitor (IC50: 13.5 μM).
T11374 GCN2-IN-6 Others , PERK
GCN2-IN-6 is also a eIF2α kinase PERK inhibitor with an IC50 of 0.26 nM (in enzymatic assay) and 230 nM (in cells). GCN2-IN-6  is a potent, and orally available GCN2 inhibitor confirmed by in-house enzymatic (IC50 of 1.8...
T2665 4EGI-1 4EGI 1 Apoptosis , PERK , Autophagy
4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM).
T3207 Briciclib ON 014185 CDK , PERK , Autophagy
Briciclib (ON 014185) is a small molecule that suppresses cyclin D1 accumulation in Y cells.
T11373 GCN2-IN-1 A-92 Others
GCN2-IN-1 (A-92) is an effective GCN2 inhibitor and can be used in research on the treatment of cancer as a chemotherapeutic agent.
T9149 2BAct 2B-Act,2B Act PERK
2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response
TQ0131 Rocaglamide Rocaglamide A,Roc-A HSP , NF-κB , PERK
Rocaglamide (Roc-A), isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB activation in T-cells.
T5173 SBI-0640756 SBI 0640756,SBI-756 PERK , Autophagy
SBI-0640756 (SBI-756) (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.
TP2247 eukaryotic translation initiation factor 3 Others
Eukaryotic initiation factors (eIF) are proteins involved in the initiation phase of eukaryotic translation. Eukaryotic translation initiation factor 3 binds to the ribosome subunit-mRNA complex. It has been implicated i...
TargetMol